4-(aminosulfonyl)-n-[(2,4,6-trifluorophenyl)methyl]-benzamide

**Description:** 4-(Aminosulfonyl)-N-[(2,4,6-Trifluorophenyl)Methyl]-Benzamide is a synthetic small molecule compound with the molecular formula C14H11F3N2O3S and a molecular weight of approximately 344.31 g/mol[1][2][3]. It is classified as a benzamide derivative containing both sulfonamide and trifluoromethyl functional groups. This compound has been studied primarily as an experimental inhibitor of carbonic anhydrase II (CA II), an enzyme involved in the reversible hydration of carbon dioxide[2][6]. Structural studies have shown it binds tightly to CA II (Kd ~3.9 nM), making it a potent inhibitor[2][6]. The compound has not been approved for any therapeutic use and remains at the experimental stage.

Other names

4-sulfamoyl-n-[(2,4,6-trifluorophenyl)methyl]benzamide4-sulfamoyl-n-(2,4,6-trifluorobenzyl)benzamide